Description

2-Ethoxycarbonylmethyl-3-Oxo-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative that serves as a critical building block in advanced organic synthesis. Its primary importance lies in its role as a versatile and reactive intermediate for constructing complex pharmaceutical molecules, particularly in the development of protease inhibitors and other active pharmaceutical ingredients (APIs). This compound is essential for research institutions and manufacturers in the pharmaceutical and fine chemical industries who require reliable, high-purity intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting viral proteases and other enzymatic pathways.
• Protease Inhibitor Development: Used in the research and production of novel protease inhibitors for therapeutic applications.
• Peptidomimetic Synthesis: Serves as a crucial scaffold for creating peptidomimetics, which are designed to mimic peptides with improved stability and bioavailability.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specialized piperazine chemistry.
• Academic & Industrial Research: Utilized in medicinal chemistry research for exploring new chemical entities and structure-activity relationships (SAR).
• Fine Chemical Production: Acts as an intermediate in the multi-step synthesis of other high-value, specialized fine chemicals.

Basic Information

Product Name	2-Ethoxycarbonylmethyl-3-Oxo-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	168160-77-8
Molecular Formula	C14H24N2O5
Molecular Weight	300.35 g/mol
Synonyms	1-Boc-3-oxo-2-(ethoxycarbonylmethyl)piperazine; tert-Butyl 2-(ethoxycarbonylmethyl)-3-oxopiperazine-1-carboxylate; 2-(Ethoxycarbonylmethyl)-3-oxo-1-piperazinecarboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-2-(ethoxycarbonylmethyl)-3-oxopiperazine; 3-Oxo-2-(ethoxycarbonylmethyl)piperazine-1-carboxylic acid tert-butyl ester; BOC-3-oxo-2-(ethoxycarbonylmethyl)piperazine; 168160-77-8
EINECS	Contact for details

Quality Control

Our 2-Ethoxycarbonylmethyl-3-Oxo-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. We adhere to cGMP (current Good Manufacturing Practice) standards where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.