Description

1,1-Difluorocyclopropane-1-Dibenzosuberyl Piperazine Dihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluorocyclopropane and dibenzosuberyl piperazine structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel therapeutic agents targeting central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of next-generation drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Preclinical Development: Serves as a critical material for producing batches of candidate drugs for pharmacological and toxicological evaluation.
• Academic Research: Employed in university and institutional labs for studying fluorinated cyclopropane chemistry and its biological effects.
• Process Chemistry: Used in route scouting and scale-up development for efficient and cost-effective API manufacturing processes.
• Reference Standard: High-purity grades are suitable for use as analytical reference standards in quality control laboratories.

Basic Information

Item	Details
Product Name	1,1-Difluorocyclopropane-1-Dibenzosuberyl Piperazine Dihydrochloride
CAS No.	167155-78-4
Molecular Formula	C22H26Cl2F2N2
Molecular Weight	427.36 g/mol
Synonyms	1,1-Difluoro-1-(dibenzosuberyl)piperazinium cyclopropane dihydrochloride; 1-(Dibenzosuberyl)-4-(1,1-difluorocyclopropyl)piperazine dihydrochloride; 1,1-Difluorocyclopropane-1-dibenzosuberylpiperazine dihydrochloride; 4-(1,1-Difluorocyclopropyl)-1-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)piperazine dihydrochloride; DBSP-Difluorocyclopropane Dihydrochloride
EINECS	Contact for details

Quality Control

Our 1,1-Difluorocyclopropane-1-Dibenzosuberyl Piperazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal quality standards and regulatory requirements for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.