Description

trans-3,4-Dihydroxypiperidine-1-Carboxylic Acid Benzyl Ester is a versatile and high-purity chiral piperidine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its functionalized structure, which provides multiple points for chemical modification, making it indispensable for constructing complex molecular architectures. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for neurological and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) targets.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereochemical complexity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs due to its modifiable hydroxyl and ester groups.
• Chemical Biology Probes: Serves as a scaffold for developing enzyme inhibitors or molecular probes to study biological pathways.
• Custom Synthesis: A starting material for the contract manufacturing of specialty fine chemicals and custom APIs.
• Academic Research: Utilized in universities and R&D labs for methodological development in organic chemistry and catalysis.

Basic Information

Product Name	trans-3,4-Dihydroxypiperidine-1-Carboxylic Acid Benzyl Ester
CAS No.	167097-00-9
Molecular Formula	C13H17NO4
Molecular Weight	251.28 g/mol
Synonyms	Benzyl trans-3,4-dihydroxypiperidine-1-carboxylate; 1-Carbobenzyloxy-3,4-dihydroxypiperidine; 1-Cbz-3,4-dihydroxypiperidine; trans-1-(Benzyloxycarbonyl)-3,4-dihydroxypiperidine; 3,4-Dihydroxy-1-piperidinecarboxylic acid phenylmethyl ester; 1-N-CBZ-3,4-DIHYDROXYPIPERIDINE; (3R,4R)-1-[(Benzyloxy)carbonyl]-3,4-dihydroxypiperidine; (3S,4S)-1-[(Benzyloxy)carbonyl]-3,4-dihydroxypiperidine
EINECS	Contact for details

Quality Control

Our trans-3,4-Dihydroxypiperidine-1-Carboxylic Acid Benzyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.