Description

2-Bromo-4-(4-Methylpiperazin-1-Yl)Aniline is a high-purity, advanced pharmaceutical intermediate characterized by its distinct bromine and substituted piperazine functional groups. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling the development of targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel drug candidates, particularly in oncology and central nervous system (CNS) research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Organic Synthesis Building Block: Used in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig amination, to construct complex heterocyclic systems.
• Research & Development (R&D): Serves as a valuable reagent in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Kinase Inhibitor Synthesis: Employed in the development of targeted kinase inhibitors for cancer therapy.
• CNS Drug Development: Used as a scaffold in the research of compounds targeting neurological disorders.
• Agrochemical Intermediate: Potential use in the synthesis of advanced crop protection agents.

Basic Information

Product Name	2-Bromo-4-(4-Methylpiperazin-1-Yl)Aniline
CAS No.	166818-86-6
Molecular Formula	C11H16BrN3
Molecular Weight	270.17 g/mol
Synonyms	2-Bromo-4-(4-methyl-1-piperazinyl)aniline; 4-(4-Methylpiperazin-1-yl)-2-bromoaniline; 2-Bromo-4-(N-methylpiperazino)aniline; 1-(5-Amino-2-bromophenyl)-4-methylpiperazine; Benzenamine, 2-bromo-4-(4-methyl-1-piperazinyl)-; 166818-86-6
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-(4-Methylpiperazin-1-Yl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and propensity for oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.