Description

3-Quinolinamine, 1,2,3,4-Tetrahydro-n-Methyl-, (R)-, (Z)-2-Butenedioate (1:1) is a high-purity chiral intermediate of significant interest in advanced pharmaceutical synthesis. This compound matters because it provides a critical, enantiomerically pure building block for the development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and neurological research. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for creating complex molecules where stereochemical integrity is paramount for biological activity and regulatory approval.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially for neurological targets.
• Asymmetric Synthesis: Used in catalytic and stoichiometric asymmetric reactions to introduce the tetrahydroquinoline scaffold with defined stereochemistry.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Reference Standard: Employed as an analytical standard for method development and quality control in API manufacturing.
• Precursor for Alkaloid Analogues: Used in the synthesis of tetrahydroquinoline-based natural product analogues and novel bioactive compounds.

Basic Information

Product Name	3-Quinolinamine, 1,2,3,4-Tetrahydro-n-Methyl-, (R)-, (Z)-2-Butenedioate (1:1)
CAS No.	166742-97-8
Molecular Formula	C14H18N2O4
Molecular Weight	278.31 g/mol
Synonyms	(R)-1,2,3,4-Tetrahydro-N-methyl-3-quinolinamine (Z)-2-butenedioate (1:1); (R)-1-Methyl-1,2,3,4-tetrahydroquinolin-3-amine maleate; (R)-N-Methyl-1,2,3,4-tetrahydroquinolin-3-amine maleate; (R)-3-Amino-N-methyl-1,2,3,4-tetrahydroquinoline maleate salt; (R)-N-Methyl-1,2,3,4-tetrahydro-3-quinolinamine maleate; (R)-1,2,3,4-Tetrahydro-N-methyl-3-quinolinamine maleate; (R)-TQMA maleate; Maleic acid salt of (R)-N-Methyl-1,2,3,4-tetrahydroquinolin-3-amine
EINECS	Contact for details

Quality Control

Our 3-Quinolinamine, 1,2,3,4-Tetrahydro-n-Methyl-, (R)-, (Z)-2-Butenedioate (1:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP intermediate applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.