Description

n-Boc-Piperazine-2-(S)-Carboxamide is a high-purity, chiral piperazine derivative protected with a tert-butoxycarbonyl (Boc) group. This compound serves as a critical chiral building block and intermediate in the synthesis of complex pharmaceutical molecules, particularly those targeting the central nervous system. It is essential for research and development chemists in the pharmaceutical and biotechnology industries who require enantiomerically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in neurological and psychiatric drug candidates.
• Peptidomimetics & Constrained Peptides: Used to introduce chiral, constrained piperazine scaffolds into peptide backbones to enhance metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective chemical transformations.
• Medicinal Chemistry Research: A versatile building block for constructing focused libraries of novel chemical entities in drug discovery programs.
• Process Chemistry & Scale-up: Serves as a validated intermediate for the kilogram-scale production of candidate drugs under GMP conditions.

Basic Information

Product Name	n-Boc-Piperazine-2-(S)-Carboxamide
CAS No.	166520-12-3
Molecular Formula	C10H19N3O3
Molecular Weight	229.28 g/mol
Synonyms	(S)-1-Boc-piperazine-2-carboxamide; (S)-1-(tert-Butoxycarbonyl)piperazine-2-carboxamide; (S)-N-Boc-piperazine-2-carboxamide; tert-Butyl (S)-2-carbamoylpiperazine-1-carboxylate; (2S)-1-[(2-Methylpropan-2-yl)oxycarbonyl]piperazine-2-carboxamide; BOC-PIPERAZINE-2-(S)-CARBOXAMIDE; (S)-1-Boc-2-piperazinecarboxamide
EINECS	Contact for details

Quality Control

Our n-Boc-Piperazine-2-(S)-Carboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.