Description

S-Acetyl-Peg20 Alcohol is a high-purity, acetyl-terminated polyethylene glycol (PEG) derivative, specifically a 20-unit PEG monomethyl ether capped with an acetyl group. This compound is valued for its role as a versatile intermediate and functionalizing agent in advanced synthesis, offering a hydrophilic spacer and a reactive handle for further conjugation. It is primarily utilized by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for developing drug delivery systems, PEGylated therapeutics, and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of prodrugs and active pharmaceutical ingredients (APIs) requiring PEGylation to enhance solubility and pharmacokinetics.
• Bioconjugation Linker: Used to attach drugs, dyes, or other molecules to proteins, peptides, or nanoparticles, leveraging the PEG chain to improve biocompatibility and reduce immunogenicity.
• Polymer Chemistry: Serves as a functional initiator or monomer in the controlled synthesis of block copolymers and hydrogels for biomedical applications.
• Surface Modification: Employed to create hydrophilic, protein-resistant coatings on medical devices, diagnostic sensors, and other biomaterial surfaces.
• Cross-linking Agent: Utilized in the preparation of cross-linked networks for controlled-release matrices and tissue engineering scaffolds.
• Research & Development: A critical reagent in life science research for studying PEGylation effects and developing novel therapeutic modalities.

Basic Information

Product Name	S-Acetyl-Peg20 Alcohol
CAS No.	165729-83-9
Molecular Formula	C44H88O23
Molecular Weight	984.1 g/mol (approx.)
Synonyms	Acetyl-PEG20-OH; α-Acetyl-ω-hydroxy-poly(ethylene glycol) methyl ether (n=20); mPEG20-Acetate; Poly(ethylene glycol) methyl ether acetate (MW ~1000); 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-Methoxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl acetate; PEG20 Monomethyl Ether Acetate
EINECS	Contact for details

Quality Control

Our S-Acetyl-Peg20 Alcohol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended long-term storage at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
PEG Content (NMR)	n ≈ 20 (MW ~1000)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.