Description

(R)-1-Boc-3-Methylpiperazine is a high-purity chiral piperazine derivative, serving as a critical building block in modern organic synthesis. Its primary value lies in its role as a key intermediate for constructing complex, biologically active molecules, particularly in the pharmaceutical sector. This compound is essential for research and development chemists and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries who require enantiomerically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of central nervous system (CNS) drugs, kinase inhibitors, and antiviral agents.
• Agrochemical Synthesis: Used in the research and production of advanced, enantiomerically pure pesticides and herbicides where specific stereochemistry is required for efficacy.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce stereoselectivity.
• Peptidomimetics Research: Employed in medicinal chemistry to create constrained peptide analogs and protease inhibitors by incorporating the piperazine scaffold.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) working on client-specific novel chemical entities.

Basic Information

Item	Details
Product Name	(R)-1-Boc-3-Methylpiperazine
CAS No.	163765-44-4
Molecular Formula	C10H20N2O2
Molecular Weight	200.28 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-3-methylpiperazine; (R)-3-Methyl-1-Boc-piperazine; (R)-N-Boc-3-methylpiperazine; tert-Butyl (R)-3-methylpiperazine-1-carboxylate; (R)-1-Boc-3-methylpiperazine; (R)-1-N-Boc-3-methylpiperazine; (3R)-1-[(2-Methylpropan-2-yl)oxycarbonyl]-3-methylpiperazine; (R)-3-Methyl-1-(tert-butoxycarbonyl)piperazine
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-3-Methylpiperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR for structural confirmation, and purity assessment. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.