Description

1-[4-(4-Benzyl-Piperazin-1-Yl)-Phenyl]-Ethanone is a high-purity, advanced pharmaceutical intermediate featuring a benzyl-piperazine substituted acetophenone core structure. This compound is of significant commercial importance for its role as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapies. It is primarily sought by research institutions, custom synthesis firms, and pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules, especially those targeting neurological pathways.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemists exploring new chemical entities and structure-activity relationships (SAR).
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for the production of client-specific compounds and reference standards.
• API Manufacturing: Integral in the production scale-up of final active pharmaceutical ingredients requiring the benzyl-piperazine pharmacophore.
• Biochemical Research: Employed in the study of enzyme inhibition and receptor binding assays due to its specific molecular architecture.

Basic Information

Product Name	1-[4-(4-Benzyl-Piperazin-1-Yl)-Phenyl]-Ethanone
CAS No.	163733-55-9
Molecular Formula	C19H22N2O
Molecular Weight	294.39 g/mol
Synonyms	1-[4-(4-Benzylpiperazin-1-yl)phenyl]ethanone; 4'-Benzylpiperazinoacetophenone; 4-Acetylphenyl 4-benzylpiperazine-1-carboxylate (tautomer); 1-[4-(4-Benzyl-1-piperazinyl)phenyl]ethanone; 4-(4-Benzylpiperazin-1-yl)acetophenone; 4-Acetyl-N-(phenylmethyl)-1-piperazineethanamine; Ethanone, 1-[4-(4-benzyl-1-piperazinyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 1-[4-(4-Benzyl-Piperazin-1-Yl)-Phenyl]-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.