Description

Ratjadone A is a potent and specific natural product inhibitor of CRM1-mediated nuclear export, making it a critical tool for studying cellular transport mechanisms and signal transduction pathways. Its high biological activity and selectivity are of significant interest for advanced life science research and drug discovery efforts. This compound is primarily utilized by researchers in pharmaceutical R&D, academic biochemistry, and oncology research to investigate novel therapeutic targets and cellular processes.

Application

• Biochemical Research: As a key reagent for studying nuclear-cytoplasmic transport, CRM1 (Exportin 1) function, and the regulation of tumor suppressor proteins.
• Drug Discovery & Target Validation: Used in high-throughput screening and mechanism-of-action studies to identify and validate new anti-cancer drug candidates.
• Cell Biology & Signal Transduction: A tool compound for investigating cell cycle regulation, apoptosis, and the subcellular localization of transcription factors.
• Oncology Research: Employed in preclinical studies to understand and potentially inhibit the nuclear export pathways exploited by cancer cells.
• Reference Standard: Serves as an analytical standard for quality control and method development in the synthesis and purification of related compounds.

Basic Information

Product Name	Ratjadone A
CAS No.	163564-92-9
Molecular Formula	C₂₉H₄₂O₈
Molecular Weight	518.64 g/mol
Synonyms	Ratjadone A; Leptomycin A; LMB-A; (3E,5E,7E,9E,11E,13E,15E,17E,19E)-20-[(2S,3S,4S,5S,6R)-3,4-Dihydroxy-6-methyl-5-[(1E)-1-propen-1-yl]oxan-2-yl]-3,5,7,9,11,13,15,17,19-nonamethyl-10-oxoicosa-3,5,7,9,11,13,15,17,19-nonaenoic acid; CRM1 Inhibitor Ratjadone A
EINECS	Contact for details

Quality Control

Our Ratjadone A is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and potency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay results, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to prevent condensation and moisture ingress. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 98%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.