Description

2,5-Piperazinedione,1,3,6-Trimethyl-,(3R-Trans)-(9Ci) is a high-purity, stereochemically defined piperazinedione derivative. This compound serves as a critical advanced pharmaceutical intermediate and a versatile chiral building block for the synthesis of complex molecules. It is essential for research and development in the pharmaceutical and fine chemical industries, particularly for creating novel active pharmaceutical ingredients (APIs) with specific stereochemical requirements.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and production of proprietary drugs and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Serves as a constrained scaffold for designing and synthesizing novel peptide analogs and enzyme inhibitors.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in stereoselective organic synthesis.
• Medicinal Chemistry: Building block for constructing libraries of compounds in drug discovery programs targeting various diseases.
• Fine Chemical Production: Intermediate in the multi-step synthesis of specialty chemicals requiring high stereochemical purity.
• Academic & Contract Research: Used in university and CRO (Contract Research Organization) laboratories for methodological development and biochemical studies.

Basic Information

Product Name	2,5-Piperazinedione,1,3,6-Trimethyl-,(3R-Trans)-(9Ci)
CAS No.	162990-28-5
Molecular Formula	C7H12N2O2
Molecular Weight	156.18 g/mol
Synonyms	(3R,6S)-1,3,6-Trimethylpiperazine-2,5-dione; (3R-trans)-1,3,6-Trimethyl-2,5-piperazinedione; (3R,6S)-1,3,6-Trimethyl-2,5-diketopiperazine; (3R,6S)-1,3,6-Trimethylpiperazine-2,5-diketone; 1,3,6-Trimethyl-2,5-diketopiperazine (stereospecific); (3R,6S)-TMPD; Chiral TMPD; Stereoisomer of Cyclo(L-alanyl-L-alanyl)
EINECS	Contact for details

Quality Control

Our 2,5-Piperazinedione,1,3,6-Trimethyl-,(3R-Trans)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical and stereochemical purity, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.