Description

Carbamic Acid, [(1S,2S,4S)-4-Amino-2-Hydroxy-5-Phenyl-1-(Phenylmethyl)Pentyl]-, 5-Thiazolylmethyl Ester, Dihydrochloride is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. This compound, with CAS number 162990-03-6, is valued for its complex stereochemistry and functional groups, which make it a critical building block for the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on targeted therapies.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Protease Inhibitor Research: Used in the development and study of novel protease inhibitors due to its specific amino acid-like backbone and functionalization.
• Peptidomimetic Chemistry: Serves as a sophisticated scaffold for constructing peptidomimetics, which are designed to mimic peptides but with enhanced stability and bioavailability.
• Asymmetric Synthesis: Employed as a starting material or intermediate in asymmetric catalytic reactions to introduce specific stereocenters into target molecules.
• Medicinal Chemistry & SAR Studies: Utilized in structure-activity relationship (SAR) studies to explore and optimize the biological activity of lead compounds.
• Reference Standard: Supplied as a high-purity analytical reference standard for quality control and method development in API manufacturing.

Basic Information

Item	Details
Product Name	Carbamic Acid, [(1S,2S,4S)-4-Amino-2-Hydroxy-5-Phenyl-1-(Phenylmethyl)Pentyl]-, 5-Thiazolylmethyl Ester, Dihydrochloride
CAS No.	162990-03-6
Molecular Formula	C24H30N3O3S • 2HCl
Molecular Weight	505.49 g/mol (Free base: 432.58 g/mol)
Synonyms	(1S,2S,4S)-4-Amino-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl 5-thiazolylmethylcarbamate dihydrochloride; (3S)-3-Amino-4-[(2S)-2-hydroxy-3-phenyl-1-(phenylmethyl)propyl]amino-1-(1,3-thiazol-5-yl)butan-2-one dihydrochloride (related form); A thiazolylmethyl carbamate derivative; Chiral phenylalanine-derived intermediate; Pharmaceutical building block 162990-03-6.
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our quality protocols are designed to meet the exacting standards of pharmaceutical R&D and cGMP starting material requirements. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.