Description

α-[2-(4-Methoxyphenyl)-2-Oxo-1-[(3,4,5-Trimethoxyphenyl)Methyl]Ethylidene]-1,3-Benzodioxole-5-Acetic Acid Sodium Salt is a high-purity, non-racemic synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound is valued for its complex molecular architecture, which serves as a critical building block in the synthesis of novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of targeted small-molecule drugs, particularly in oncology and neurology.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a reference standard and a starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: Employed in the study of enzyme inhibition and receptor binding assays due to its specific stereochemistry and functional groups.
• Custom Synthesis: A foundational compound for contract research organizations (CROs) and CDMOs producing bespoke molecules for client projects.

Basic Information

Product Name	α-[2-(4-Methoxyphenyl)-2-Oxo-1-[(3,4,5-Trimethoxyphenyl)Methyl]Ethylidene]-1,3-Benzodioxole-5-Acetic Acid Sodium Salt
CAS No.	162412-70-6
Molecular Formula	C28H25NaO9
Molecular Weight	528.49 g/mol
Synonyms	Sodium (Z)-2-(2-(benzo[d][1,3]dioxol-5-yl)-2-((4-methoxyphenyl)(oxo)methyl)-3-(3,4,5-trimethoxybenzyl)prop-2-en-1-yl)acetate; (Z)-α-[2-(4-Methoxyphenyl)-2-Oxo-1-[(3,4,5-Trimethoxyphenyl)Methyl]Ethylidene]-1,3-Benzodioxole-5-Acetic Acid Sodium Salt; Sodium (Z)-2-(benzo[d][1,3]dioxol-5-yl)-2-((4-methoxyphenyl)(oxo)methyl)-3-(3,4,5-trimethoxybenzyl)allylacetate; CAS 162412-70-6; 1,3-Benzodioxole-5-acetic acid, α-[2-(4-methoxyphenyl)-2-oxo-1-[(3,4,5-trimethoxyphenyl)methyl]ethylidene]-, sodium salt, (Z)-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for research and pre-clinical development. Every batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and mass spectrometry. While typically supplied as a research-grade material, synthesis under controlled conditions aligned with ICH Q7 guidelines is available upon request for development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.