Description

Cyclopropanecarbonyl Chloride, 2,2,3-Trimethyl-, trans- (9Ci) is a specialized, high-purity organic intermediate featuring a functionalized cyclopropane ring system. This compound matters for its role as a critical building block in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is needed by R&D chemists and process development teams working on advanced active ingredients, where its unique sterically hindered structure enables the introduction of the cyclopropane moiety, a motif known for conferring desirable metabolic stability and conformational rigidity to target compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in therapeutic areas requiring conformationally constrained molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cyclopropane group can enhance biological activity.
• Material Science Research: Serves as a precursor for monomers or ligands in the development of specialized polymers and advanced functional materials.
• Organic Synthesis & Method Development: A valuable reagent in academic and industrial laboratories for studying cyclopropane chemistry and developing new synthetic methodologies.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fragrance and flavor ingredients.

Basic Information

Product Name	Cyclopropanecarbonyl Chloride, 2,2,3-Trimethyl-, trans- (9Ci)
CAS No.	162224-59-1
Molecular Formula	C7H11ClO
Molecular Weight	146.62 g/mol
Synonyms	trans-2,2,3-Trimethylcyclopropanecarbonyl Chloride; (1R,2S)-rel-2,2,3-Trimethylcyclopropanecarboxylic Acid Chloride; 2,2,3-Trimethylcyclopropanecarbonyl Chloride, trans-; 2,2,3-Trimethylcyclopropanecarboxylic Acid Chloride; Cyclopropanecarboxylic acid, 2,2,3-trimethyl-, chloride, trans-; (1R,2S)-2,2,3-Trimethylcyclopropanecarbonyl Chloride
EINECS	Contact for details

Quality Control

Our Cyclopropanecarbonyl Chloride, 2,2,3-Trimethyl-, trans- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and isomeric consistency. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific customer requirements for research or cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Isolate from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Isomeric Purity (trans-)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.