Description

1-((7,7-Dimethyl-2(S)-(2(S)-Amino-4-(Methylsulfonyl)Butyramido)Bicyclo[2,2,1]Heptan-1(S)-Yl)Methylsulfonyl)-4-(2-Methylphenyl)Piperazine Hydrochloride is a high-purity, non-natural amino acid derivative featuring a complex bicyclic structure and a piperazine moiety. This compound serves as a critical chiral building block and advanced intermediate in modern pharmaceutical research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents, particularly those targeting neurological and cardiovascular pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to construct complex peptide analogs and peptidomimetics due to its constrained bicyclic amino acid structure.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Neurological & Cardiovascular Drug Development: Serves as a building block for potential therapeutics targeting GPCRs and ion channels relevant to CNS and cardiovascular diseases.
• Process Chemistry & Scale-Up: Supplied for route scouting, process optimization, and pilot-scale synthesis of candidate drugs.
• Bioconjugation & Probe Development: Can be used in the synthesis of labeled compounds or molecular probes for biochemical assays.

Basic Information

Product Name	1-((7,7-Dimethyl-2(S)-(2(S)-Amino-4-(Methylsulfonyl)Butyramido)Bicyclo[2,2,1]Heptan-1(S)-Yl)Methylsulfonyl)-4-(2-Methylphenyl)Piperazine Hydrochloride
CAS No.	160312-62-9
Molecular Formula	C26H41ClN4O5S2
Molecular Weight	605.20 g/mol
Synonyms	(1S,2S,4S)-1-[[(2S)-2-Amino-4-(methylsulfonyl)butanoyl]amino]-7,7-dimethylbicyclo[2.2.1]heptane-2-methanesulfonic acid 4-(2-methylphenyl)piperazinyl ester hydrochloride; N-[(1S,2S,4S)-2-[(Methylsulfonyl)methyl]-7,7-dimethylbicyclo[2.2.1]hept-1-yl]-L-2-amino-4-(methylsulfonyl)butanamide 4-(2-Methylphenyl)piperazine hydrochloride; Bicyclo[2.2.1]heptane-2-methanesulfonic acid derivative hydrochloride; Advanced Chiral Piperazine Intermediate; CAS 160312-62-9
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict quality management systems. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet client-specific requirements for R&D or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to maintain stability. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.