Description

1-Palmitoyl-2-Linoleoyl-Sn-Glycero-3-Phosphocholine is a high-purity, synthetic phospholipid with a defined fatty acid composition, serving as a critical building block for advanced lipid-based formulations. Its precisely engineered structure provides superior consistency and performance compared to natural extracts, making it essential for research and development requiring exact molecular control. This compound is primarily utilized by the pharmaceutical, biotechnology, and advanced cosmetics industries for creating liposomes, lipid nanoparticles (LNPs), and other sophisticated delivery systems.

Application

• Drug Delivery Systems: A key excipient for formulating stable liposomes and lipid nanoparticles (LNPs) for mRNA, siRNA, and small molecule therapeutics.
• Biomembrane Research: Used as a standard or model phospholipid in biophysical studies to investigate membrane fluidity, permeability, and protein-lipid interactions.
• Cosmetic Actives: Incorporated into high-end skincare products like anti-aging serums and restorative creams for its biomimetic and skin-barrier enhancing properties.
• Diagnostic Reagents: Serves as a component in diagnostic kits and assays that utilize liposomal encapsulation for signal amplification.
• Cell Culture & Media Supplements: Employed in specialized cell culture applications to support the growth of sensitive cell lines.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality control in lipidomics.

Basic Information

Item	Detail
Product Name	1-Palmitoyl-2-Linoleoyl-Sn-Glycero-3-Phosphocholine
CAS No.	159701-21-0
Molecular Formula	C42H80NO8P
Molecular Weight	758.06 g/mol
Synonyms	PLPC; 1-Palmitoyl-2-linoleoyl-phosphatidylcholine; 16:0-18:2 PC; POPC (Note: This is a common but incorrect synonym for this specific isomer; the correct systematic name is PLPC); (2R)-2,3-Bis[[(Z)-octadec-9-enoyl]oxy]propyl 2-(trimethylazaniumyl)ethyl phosphate; 1-Hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine; Phosphatidylcholine (16:0/18:2(9Z,12Z))
EINECS	Contact for details

Quality Control

Every batch of 1-Palmitoyl-2-Linoleoyl-Sn-Glycero-3-Phosphocholine is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to verify identity, purity, and fatty acid composition. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet cGMP, ISO, or research-grade standards as required.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic and easily oxidized nature, store under an inert atmosphere (e.g., argon or nitrogen) at -20°C or below for long-term stability. For short-term use, store at 2-8°C. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder or waxy solid
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 98.0%
Fatty Acid Composition (GC)	Palmitic Acid (16:0): 45-55% Linoleic Acid (18:2): 45-55%
Water Content (KF)	≤ 1.0%
Peroxide Value	≤ 3.0 meq/kg
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.