Description

tert-Butyl 4-[4-(Hydroxymethyl)Phenyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is a high-value, protected piperazine derivative that serves as a critical pharmaceutical intermediate and building block in advanced organic synthesis. Its molecular structure, featuring both a hydroxymethylphenyl group and a Boc-protected amine, makes it an essential precursor for constructing complex molecules with specific biological activity. This compound is primarily sought by research organizations and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly within medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Peptidomimetic Synthesis: Serves as a constrained scaffold for creating peptide analogs with improved metabolic stability and bioavailability.
• Ligand and Receptor Probe Development: Employed in the construction of chemical probes for biological target identification and validation.
• Custom Synthesis: A versatile starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Chemical Library Production: Used to generate diverse compound libraries for high-throughput screening (HTS) in drug discovery.

Basic Information

Product Name	tert-Butyl 4-[4-(Hydroxymethyl)Phenyl]Tetrahydro-1(2H)-Pyrazinecarboxylate
CAS No.	158985-37-6
Molecular Formula	C16H24N2O3
Molecular Weight	292.38 g/mol
Synonyms	1-Boc-4-(4-Hydroxymethylphenyl)piperazine; tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperazine-1-carboxylate; 4-(4-Hydroxymethylphenyl)-1-piperazinecarboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(4-hydroxymethylphenyl)piperazine; 158985-37-6; Boc-4-(4-Hydroxymethylphenyl)piperazine; N-Boc-4-(4-Hydroxymethylphenyl)piperazine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[4-(Hydroxymethyl)Phenyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. For projects requiring specific regulatory support, we can discuss documentation aligned with ICH guidelines and current Good Manufacturing Practices (cGMP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.