Description

1-Boc-4-(4-Hydroxy-Phenyl)-Piperazine is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile, reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new drug candidates, especially within the fields of central nervous system (CNS) therapeutics and oncology.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for receptor-targeted drugs.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization stages to explore structure-activity relationships (SAR).
• Peptidomimetic Synthesis: Serves as a constrained scaffold to mimic peptide secondary structures in drug design.
• Ligand Development: Employed in creating selective ligands for neurological targets such as serotonin and dopamine receptors.
• Chemical Biology Probes: Utilized to develop tool compounds for studying biological pathways and protein function.
• Custom Synthesis Building Block: Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.

Basic Information

Product Name	1-Boc-4-(4-Hydroxy-Phenyl)-Piperazine
CAS No.	158985-25-2
Molecular Formula	C15H22N2O3
Molecular Weight	278.35 g/mol
Synonyms	1-Boc-4-(4-Hydroxyphenyl)piperazine; tert-Butyl 4-(4-hydroxyphenyl)piperazine-1-carboxylate; 4-(4-Hydroxyphenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(4-hydroxyphenyl)piperazine; N-Boc-4-(4-Hydroxyphenyl)piperazine; 158985-25-2; BOC-4-(4-Hydroxy-Phenyl)-Piperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(4-Hydroxy-Phenyl)-Piperazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting regulatory documentation and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.