Description

1β-Eldecalcitol is a synthetic, active vitamin D3 analog designed for enhanced metabolic stability and potency. This compound is critical for researchers and manufacturers developing advanced therapeutics targeting bone metabolism and related endocrine pathways. It is primarily utilized in the pharmaceutical industry for the R&D and production of next-generation treatments for osteoporosis and other disorders of calcium regulation.

Application

• Pharmaceutical Active Ingredient: Key intermediate or active pharmaceutical ingredient (API) in the synthesis of prescription medications for osteoporosis and renal osteodystrophy.
• Biochemical Research: A vital tool in life science research for studying vitamin D receptor (VDR) activation, gene expression, and cellular differentiation processes.
• Preclinical Development: Used in animal studies and pharmacological models to investigate efficacy, pharmacokinetics, and safety profiles of new drug candidates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Metabolic Studies: Employed in research focused on calcium and phosphate homeostasis, bone mineralization, and endocrine function.

Basic Information

Product Name	1β-Eldecalcitol
CAS No.	158689-03-3
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	Eldecalcitol; 1β,25-Dihydroxy-2β-(3-hydroxypropoxy)vitamin D3; ED-71; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5S)-5-Ethyl-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-1,3-cyclohexanediol; 1β-Hydroxyeldecalcitol; 2β-(3-Hydroxypropoxy)-1α,25-dihydroxyvitamin D3
EINECS	Contact for details

Quality Control

Our 1β-Eldecalcitol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of related substances. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.