Description

(S)-Piperazine-2-Carboxylic Acid Dihydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its enantiomeric purity makes it a critical component in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals where stereochemistry is essential. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutics.
• Peptide Synthesis: Serves as a protected derivative of (S)-piperazine-2-carboxylic acid for the incorporation of the piperazine moiety into complex peptide structures.
• Ligand and Catalyst Preparation: Used in the synthesis of chiral ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Agrochemical Research: Building block for creating enantiomerically pure pesticides and herbicides with improved efficacy and environmental profiles.
• Academic & R&D: Fundamental reagent in medicinal chemistry research for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	(S)-Piperazine-2-Carboxylic Acid Dihydrochloride
CAS No.	158663-69-5
Molecular Formula	C5H12Cl2N2O2
Molecular Weight	203.07 g/mol
Synonyms	(S)-2-Piperazinecarboxylic Acid Dihydrochloride; (S)-Piperazine-2-carboxylic Acid Dihydrochloride; D-Pipecolinic Acid Dihydrochloride (related isomer); L-Pipecolic Acid Dihydrochloride Derivative; (S)-Aminopiperidine-2-carboxylic Acid Dihydrochloride; (2S)-Piperazine-2-carboxylic Acid Dihydrochloride; (S)-PCA Dihydrochloride; (S)-2-Carboxypiperazine Dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-Piperazine-2-Carboxylic Acid Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.