Description

[R-(R*,S*)]-3-tert-Butylcarbamoyl-4-Oxiranylmethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a sophisticated chiral piperazine derivative featuring both oxirane (epoxide) and tert-butyl carbamate protecting groups. This compound matters as a high-value pharmaceutical intermediate and chiral building block for the synthesis of complex active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical industry, particularly those developing protease inhibitors, kinase inhibitors, and other targeted therapeutics where precise stereochemistry is critical.

Application

• Key Intermediate in API Synthesis: Serves as a critical chiral scaffold in the multi-step synthesis of complex drug molecules, especially those targeting viral and oncological pathways.
• Chiral Building Block for Medicinal Chemistry: Used in research and development for constructing novel chemical entities with defined stereocenters, essential for drug discovery programs.
• Protease Inhibitor Precursor: A potential intermediate in the synthesis of compounds designed to inhibit specific proteases, such as those involved in viral replication.
• Chemical Biology Probe Development: Employed in the creation of tool compounds and probes for studying enzyme function and biological pathways due to its reactive epoxide moiety.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke intermediates under cGMP conditions.
• Academic and Industrial Research: Utilized in synthetic organic chemistry research focused on novel heterocycle formation and stereoselective transformations.

Basic Information

Product Name	[R-(R*,S*)]-3-tert-Butylcarbamoyl-4-Oxiranylmethyl-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	158380-45-1
Molecular Formula	C19H35N3O4
Molecular Weight	369.50 g/mol
Synonyms	(2R,3S)-1-[(tert-Butoxy)carbonyl]-4-[(oxiran-2-yl)methyl]-3-[(tert-butylcarbamoyl)]piperazine-2-carboxylic acid tert-butyl ester; tert-Butyl (2R,3S)-1-(tert-butoxycarbonyl)-4-(oxiran-2-ylmethyl)-3-(tert-butylcarbamoyl)piperazine-2-carboxylate; (2R,3S)-1-Boc-4-(oxiran-2-ylmethyl)-3-(tert-butylcarbamoyl)piperazine-2-carboxylic acid tert-butyl ester; Boc-protected Epoxy Piperazine Derivative; Chiral Epoxy Piperazine Intermediate; 158380-45-1; (S,R)-Epoxy Piperazine tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols suitable for pharmaceutical applications. Every batch is characterized and tested to ensure high chiral purity and chemical integrity. A comprehensive Certificate of Analysis (COA) is provided, detailing results for identity (IR, NMR), assay (HPLC), chiral purity (Chiral HPLC), and specified impurities. We support development and commercial projects with material produced under quality management systems aligned with ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.