Description

Tak 044 CAS NO 157380-72-8 is a specialized chemical compound, identified by CAS number 157380-72-8, valued for its role as a potent and selective antagonist of the C5a receptor. This targeted activity makes it a critical research tool for investigating inflammatory pathways and immune system modulation. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for preclinical studies and drug discovery programs focused on inflammatory and autoimmune diseases.

Application

• Pharmacological Research: Used as a reference standard and tool compound in studies investigating the role of the complement system, particularly the C5a anaphylatoxin pathway.
• Drug Discovery: Serves as a key molecular probe for validating C5a receptor (C5aR, CD88) as a therapeutic target in inflammatory and autoimmune conditions.
• Inflammation Models: Applied in in vitro and in vivo experimental models to inhibit C5a-induced cellular responses, such as chemotaxis, degranulation, and cytokine release.
• Biomarker Studies: Utilized to elucidate signaling mechanisms downstream of C5a receptor activation in immune cells like neutrophils, monocytes, and macrophages.
• Academic Research: Supports fundamental research in immunology and complement biology within university and institutional laboratories.

Basic Information

Product Name	Tak 044
CAS No.	157380-72-8
Molecular Formula	C59H84N14O11S
Molecular Weight	1173.4 g/mol
Synonyms	Tak-044; Cyclo[N-methyl-L-alanyl-L-lysyl-L-α-aspartyl-3-(2-naphthyl)-D-alanyl-L-α-aspartyl-L-tryptophyl-D-2-(3-aminopropyl)-L-ornithyl-L-α-aspartyl-D-tryptophyl-L-isoleucyl-L-α-glutamyl-L-ornithyl-L-leucyl]; C5a Receptor Antagonist, Tak-044; N-Methyl-L-alanyl-L-lysyl-L-α-aspartyl-3-(2-naphthyl)-D-alanyl-L-α-aspartyl-L-tryptophyl-D-2-(3-aminopropyl)-L-ornithyl-L-α-aspartyl-D-tryptophyl-L-isoleucyl-L-α-glutamyl-L-ornithyl-L-leucyl Cyclic (1→13)-Peptide
EINECS	Contact for details

Quality Control

Our Tak 044 is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is supported by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.