Description

(R)-(-)-Ibuprofen, (S)-(+)-Lysinate is a high-purity, non-steroidal anti-inflammatory drug (NSAID) enantiomer salt, specifically the lysine salt of the (R)-enantiomer of ibuprofen. This specific stereochemistry is critical for applications requiring the targeted biological activity of the (R)-(-)-ibuprofen isomer, offering distinct pharmacological and metabolic profiles compared to the racemic mixture or the (S)-(+)-enantiomer. It is primarily utilized in advanced pharmaceutical research and development, particularly in chiral drug synthesis, metabolic studies, and the formulation of specialized therapeutic agents. This compound is essential for scientists and manufacturers focused on precision medicine and the development of enantiomerically pure active pharmaceutical ingredients (APIs).

Application

• Chiral Pharmaceutical Intermediate: Serves as a key building block in the synthesis of enantiomerically pure non-steroidal anti-inflammatory drugs (NSAIDs) and other targeted therapeutics.
• Metabolic and Pharmacokinetic Research: Used in preclinical and clinical studies to investigate the distinct metabolic pathways, efficacy, and safety profiles of the (R)-(-)-ibuprofen enantiomer.
• Reference Standard: Employed as a high-purity analytical standard in HPLC, LC-MS, and other chromatographic methods for quality control and method validation in pharmaceutical analysis.
• Formulation Development: Utilized in R&D for developing novel drug delivery systems, such as salts with improved solubility or stability profiles for specific dosage forms.
• Biochemical Research: Applied in studies exploring enzyme selectivity, receptor binding, and the mechanistic actions of chiral NSAIDs at a molecular level.
• Process Chemistry: Acts as a starting material or intermediate in the development and scale-up of asymmetric synthesis routes for pharmaceutical manufacturing.

Basic Information

Product Name	(R)-(-)-Ibuprofen, (S)-(+)-Lysinate
CAS No.	157369-85-2
Molecular Formula	C19H32N2O4
Molecular Weight	352.47 g/mol
Synonyms	(R)-Ibuprofen Lysinate; (R)-(-)-Ibuprofen L-Lysine Salt; Dexibuprofen Lysinate; (2R)-2-[4-(2-Methylpropyl)phenyl]propanoic acid - (2S)-2,6-diaminohexanoic acid (1:1); (R)-Ibuprofen Lysine Salt; S-(+)-Lysine (R)-(-)-Ibuprofen Salt; ARX-101 (research code); L-Lysine (R)-Ibuprofen
EINECS	Contact for details

Quality Control

Our (R)-(-)-Ibuprofen, (S)-(+)-Lysinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) detailing key parameters such as assay (HPLC), enantiomeric excess, and impurity profiles. While produced to meet high standards for research use, specifications can be aligned with customer-specific requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.