Description

Licofelone is a dual cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor, representing a significant class of anti-inflammatory agents. This compound is valued for its potential to provide a broader therapeutic profile with a reduced risk of gastrointestinal side effects compared to traditional non-steroidal anti-inflammatory drugs (NSAIDs). It is primarily of interest to pharmaceutical research and development organizations, contract research organizations (CROs), and fine chemical suppliers focused on developing novel analgesic and anti-arthritic drug candidates.

Application

• Pharmaceutical R&D: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of new anti-inflammatory and analgesic medications.
• Biochemical Research: Used as a potent tool compound in pharmacological studies to investigate the dual inhibition pathways of COX and 5-LOX enzymes.
• Preclinical Studies: Employed in animal models to evaluate efficacy, pharmacokinetics, and safety profiles for conditions like osteoarthritis and rheumatoid arthritis.
• Analytical Standard: Utilized as a high-purity certified reference material (CRM) for method development, validation, and quality control testing in analytical laboratories.
• Fine Chemical Synthesis: Acts as a sophisticated building block for the synthesis of more complex molecules or analogs within medicinal chemistry programs.

Basic Information

Product Name	Licofelone
CAS No.	156897-06-2
Molecular Formula	C₂₃H₂₁ClFNO₂
Molecular Weight	397.87 g/mol
Synonyms	ML-3000; (R,S)-2-(2,4-Dichlorophenyl)-4-methyl-1-(4-(methylsulfonyl)phenyl)-1H-pyrrol-3-yl 4-(trifluoromethyl)phenyl ketone; 5-(4-Methylsulfonylphenyl)-6-(2,4-dichlorophenyl)-2,3-dihydro-1H-pyrrolizine; Licofelone [INN]; Licofelona [Spanish]; Licofelonum [Latin]
EINECS	Contact for details

Quality Control

Our Licofelone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR) to ensure it meets the stringent requirements for research and development use. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.