Description

2-Boc-7-Hydroxymethyl-Octahydro-Pyrido[1,2-A]Pyrazine is a sophisticated bicyclic piperazine derivative, serving as a critical pharmaceutical intermediate and building block in advanced organic synthesis. Its value lies in its protected amine and hydroxymethyl functionalities, which enable precise molecular construction for complex target molecules. This compound is primarily required by pharmaceutical R&D and fine chemical manufacturers engaged in developing new therapeutic agents, particularly within medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting the central nervous system (CNS) and other therapeutic areas.
• Peptidomimetic Scaffold: Used to construct constrained peptide analogs and peptidomimetics due to its rigid bicyclic structure, which can improve metabolic stability and bioavailability.
• Ligand Synthesis: Serves as a core structure for developing chelating agents, catalysts, and specialized ligands in asymmetric synthesis.
• Chemical Biology Probe Development: Employed in creating molecular probes for studying enzyme function and biological pathways.
• Academic & Industrial Research: A valuable reagent for methodology development and exploring new chemical spaces in organic and medicinal chemistry laboratories.
• Custom Synthesis Building Block: Utilized by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex, high-value molecules for clients.

Basic Information

Product Name	2-Boc-7-Hydroxymethyl-Octahydro-Pyrido[1,2-A]Pyrazine
CAS No.	156772-96-2
Molecular Formula	C14H26N2O3
Molecular Weight	270.37 g/mol
Synonyms	1-Boc-7-(hydroxymethyl)octahydro-2H-pyrido[1,2-a]pyrazine; tert-Butyl 7-(hydroxymethyl)octahydro-2H-pyrido[1,2-a]pyrazine-2-carboxylate; 2H-Pyrido[1,2-a]pyrazine-2-carboxylic acid, 7-(hydroxymethyl)octahydro-, 1,1-dimethylethyl ester; 2-(tert-Butoxycarbonyl)-7-(hydroxymethyl)octahydropyrido[1,2-a]pyrazine; Bicyclic Boc-protected amine; Boc-Protected Hydroxymethyl Pyrido-Pyrazine
EINECS	Contact for details

Quality Control

Our production of 2-Boc-7-Hydroxymethyl-Octahydro-Pyrido[1,2-A]Pyrazine adheres to stringent quality protocols suitable for GMP-aligned applications. Every batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and physical properties are provided with each shipment to guarantee batch-to-batch consistency and traceability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.