Description

Diethyl (2,2,2-Trifluoro-1-Hydroxyethyl)phosphonate is a specialized organophosphorus compound featuring a trifluoroethanol moiety. This structure is significant as it serves as a versatile fluorinated building block in advanced organic synthesis, enabling the introduction of fluorine atoms to modulate the properties of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of fluorinated drug candidates, particularly protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Building block for novel herbicides, pesticides, and plant growth regulators with enhanced activity and environmental profile.
• Material Science: Precursor for fluorinated ligands, catalysts, and monomers used in specialty polymers and coatings.
• Organic Synthesis Reagent: Used in Horner-Wadsworth-Emmons (HWE) olefination reactions to generate fluorinated alkenes.
• Fluorine Chemistry Research: Essential reagent in academic and industrial labs exploring new methodologies for C-F bond formation.

Basic Information

Product Name	Diethyl (2,2,2-Trifluoro-1-Hydroxyethyl)phosphonate
CAS No.	156748-67-3
Molecular Formula	C6H12F3O4P
Molecular Weight	236.13 g/mol
Synonyms	Diethyl (2,2,2-Trifluoro-1-hydroxyethyl)phosphonate; (2,2,2-Trifluoro-1-hydroxyethyl)phosphonic Acid Diethyl Ester; 1-Hydroxy-2,2,2-trifluoroethylphosphonic Acid Diethyl Ester; Diethyl (1-Hydroxy-2,2,2-trifluoroethyl)phosphonate; 2,2,2-Trifluoro-1-hydroxyethylphosphonic Acid Diethyl Ester; Phosphonic Acid, (2,2,2-trifluoro-1-hydroxyethyl)-, Diethyl Ester
EINECS	Contact for details

Quality Control

Our Diethyl (2,2,2-Trifluoro-1-Hydroxyethyl)phosphonate is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.