Description

3-Methoxybicyclo[1.1.1]pentane-1-carboxylic acid is a high-value, synthetically versatile bicyclic carboxylic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique, highly strained [1.1.1]propellane-derived structure makes it an essential precursor for creating complex molecular architectures with applications in pharmaceuticals and materials science. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides, leveraging its rigid bicyclic scaffold.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Materials Science Research: Employed in the creation of novel polymers and advanced materials with unique mechanical or optical properties due to its strained ring system.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes and bio-conjugation reagents to study biological systems.
• Academic and Industrial R&D: A valuable tool for methodological development in organic synthesis, including cross-coupling and C-H functionalization reactions.

Basic Information

Product Name	3-Methoxybicyclo[1.1.1]pentane-1-carboxylic Acid
CAS No.	156329-86-1
Molecular Formula	C8H12O3
Molecular Weight	156.18 g/mol
Synonyms	3-Methoxybicyclo[1.1.1]pentane-1-carboxylic acid; 1-Carboxy-3-methoxybicyclo[1.1.1]pentane; 3-Methoxy-BCP-COOH; 3-Methoxy-[1.1.1]propellane-1-carboxylic acid; Bicyclo[1.1.1]pentane-1-carboxylic acid, 3-methoxy-; 3-Methoxy-tricyclo[1.1.1.01,3]pentane-5-carboxylic acid (alternative numbering)
EINECS	Contact for details

Quality Control

Our 3-Methoxybicyclo[1.1.1]pentane-1-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0% (by titration)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.