Description

4-((R)-((2S,5R)-4-Allyl-2,5-Dimethylpiperazin-1-Yl)(3-Hydroxyphenyl)Methyl)-N,n-Diethylbenzamide CAS NO 155836-50-3 is a sophisticated chiral piperazine derivative, a high-value intermediate designed for advanced pharmaceutical synthesis and chemical research. Its complex stereochemistry and functional groups make it a critical building block for developing novel therapeutic agents, particularly in central nervous system (CNS) and receptor-targeted drug discovery. This compound is essential for medicinal chemists and R&D teams in pharmaceutical, biotechnology, and fine chemical industries seeking to create enantiomerically pure, high-potency drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potent, selective receptor modulators and enzyme inhibitors.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• CNS Drug Development: Particularly relevant for creating novel compounds targeting neurological pathways, given its piperazine pharmacophore.
• Asymmetric Synthesis: Serves as a valuable chiral auxiliary or building block in stereoselective synthesis routes.
• Preclinical Candidate Synthesis: Employed in the multistep synthesis of new chemical entities (NCEs) for biological evaluation.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and research organizations for custom synthesis projects.

Basic Information

Product Name	4-((R)-((2S,5R)-4-Allyl-2,5-Dimethylpiperazin-1-Yl)(3-Hydroxyphenyl)Methyl)-N,n-Diethylbenzamide
CAS No.	155836-50-3
Molecular Formula	C27H37N3O2
Molecular Weight	435.60 g/mol
Synonyms	4-[(1R)-1-[(2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl]-1-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide; (R)-4-((2S,5R)-4-Allyl-2,5-dimethylpiperazin-1-yl)(3-hydroxyphenyl)methyl)-N,N-diethylbenzamide; 4-[(R)-[(2S,5R)-4-Allyl-2,5-dimethylpiperazin-1-yl](3-hydroxyphenyl)methyl]-N,N-diethylbenzamide; Benzamide, 4-[(1R)-1-[(2S,5R)-4-(2-propen-1-yl)-2,5-dimethyl-1-piperazinyl]-1-(3-hydroxyphenyl)methyl]-N,N-diethyl-; 155836-50-3; Allyl-dimethylpiperazine benzamide derivative; Chiral piperazine benzamide intermediate.
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Quality Control

Our 4-((R)-((2S,5R)-4-Allyl-2,5-Dimethylpiperazin-1-Yl)(3-Hydroxyphenyl)Methyl)-N,n-Diethylbenzamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as chiral purity, chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.