Description

1-o-Hexadecyl-2-[cis-8,11,14-Eico-Satrienoyl]-Sn-Glycero-3-Phosphocholine is a synthetic, structured phospholipid analog, specifically a lysophosphatidylcholine derivative with a defined sn-1 ether linkage and a polyunsaturated fatty acid at the sn-2 position. This precise molecular architecture is critical for advanced research in membrane biophysics, lipid signaling, and drug delivery systems. It serves as an essential biochemical tool for scientists in pharmaceutical R&D, biotechnology, and academic institutions studying lipid metabolism, inflammation pathways, and the formulation of lipid-based nanoparticles.

Application

• Biochemical Research: As a key reagent for studying the role of specific phospholipids in cell membrane dynamics, lipid rafts, and signal transduction pathways.
• Lipidomics & Analytical Standards: Used as a high-purity reference standard for the identification and quantification of complex lipids in mass spectrometry-based lipidomic analyses.
• Drug Delivery Systems: A potential component in the development of liposomal and other lipid nanoparticle (LNP) formulations for targeted therapeutic delivery.
• Cell Culture & Biotechnology: Employed in specialized media formulations or as a supplement to modulate membrane properties and cell behavior in vitro.
• Enzyme Substrate Studies: Acts as a specific substrate for phospholipases (e.g., PLA2) and other lipid-modifying enzymes to investigate enzyme kinetics and inhibition.
• Model Membrane Systems: Incorporated into artificial bilayers and vesicles (liposomes) to create defined membrane models with tailored physical and functional characteristics.

Basic Information

Product Name	1-o-Hexadecyl-2-[cis-8,11,14-Eico-Satrienoyl]-Sn-Glycero-3-Phosphocholine
CAS No.	155575-01-2
Molecular Formula	C44H84NO8P
Molecular Weight	786.11 g/mol
Synonyms	1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-phosphocholine; C16:0-e-20:4 PC; 1-Hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine; LysoPAF C-16; Ether-linked Arachidonoyl Phosphatidylcholine; 1-O-Alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine; sn-Glycero-3-phosphocholine, 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-; Platelet-Activating Factor (PAF) analog
EINECS	Contact for details

Quality Control

Every batch of our high-purity phospholipids is manufactured and analyzed under strict quality management systems. Certificates of Analysis (COA) are provided, detailing comprehensive testing via HPLC, NMR, and MS to confirm identity, purity, and lipid composition. We adhere to cGMP guidelines for production where applicable, ensuring traceability and consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Phosphorus)	≥ 98% of theoretical
Solubility	Soluble in chloroform, ethanol; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.