Description

Dibenzo(C,F)(1,2)Thiazepine, 6,11-Dihydro-6-Methyl-11-(2-(1-Piperazinyl)Ethoxy)-, 5,5-Dioxide,(Z)-2-Butenedioate (1:1) is a high-purity, complex organic salt with significant pharmacological research interest. This compound matters as a key synthetic intermediate or active pharmaceutical ingredient (API) in the development of novel therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of advanced drug candidates targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a reference standard or a core scaffold for structure-activity relationship (SAR) studies in academic and industrial R&D.
• Active Pharmaceutical Ingredient (API) Development: Serves as the active moiety in the formulation development of preclinical and clinical trial materials.
• Biochemical Tool Compound: Employed in vitro and in vivo to study specific biological pathways and receptor interactions.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis for creating specialized, high-value chemical entities.

Basic Information

Product Name	Dibenzo(C,F)(1,2)Thiazepine, 6,11-Dihydro-6-Methyl-11-(2-(1-Piperazinyl)Ethoxy)-, 5,5-Dioxide,(Z)-2-Butenedioate (1:1)
CAS No.	155444-13-6
Molecular Formula	C23H27N3O7S
Molecular Weight	489.54 g/mol
Synonyms	6,11-Dihydro-6-methyl-11-[2-(1-piperazinyl)ethoxy]dibenzo[c,f][1,2]thiazepine 5,5-dioxide (Z)-2-butenedioate (1:1); Quetiapine Fumarate; Quetiapine Hemifumarate; ICI 204,636; ICI-204636; Seroquel Fumarate; (Z)-But-2-enedioic acid--6,11-dihydro-6-methyl-11-[2-(piperazin-1-yl)ethoxy]dibenzo[c,f][1,2]thiazepine 5,5-dioxide (1:1)
EINECS	Contact for details

Quality Control

Our Dibenzo(C,F)(1,2)Thiazepine, 6,11-Dihydro-6-Methyl-11-(2-(1-Piperazinyl)Ethoxy)-, 5,5-Dioxide,(Z)-2-Butenedioate (1:1) is manufactured under strict quality management systems. Production adheres to current Good Manufacturing Practice (cGMP) principles where applicable, ensuring traceability and consistency. All batches undergo rigorous analytical testing, including HPLC for purity, residual solvent analysis, and identification confirmation. Certificates of Analysis (COA) detailing full specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.