Description

Dibenzo(C,F)(1,2)Thiazepine, 6,11-Dihydro-6-Methyl-11-(2-(1-Pyrrolidinyl)Ethoxy)-, 5,5-Dioxide(Z)-2-Butenedioate (1:1) is a high-purity, non-racemic pharmaceutical intermediate of significant commercial importance. This compound matters as a key chiral building block in the synthesis of advanced active pharmaceutical ingredients (APIs), where its specific stereochemistry is critical for biological activity. It is primarily needed by pharmaceutical R&D laboratories and manufacturers engaged in the production of novel therapeutic agents, particularly within the central nervous system (CNS) and other specialized drug classes.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the multi-step synthesis of proprietary drug candidates.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for new chemical entities (NCEs), especially in neurological and psychiatric applications.
• Asymmetric Synthesis: Employed in stereoselective reactions to construct complex molecular architectures due to its defined stereocenter.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production.
• Reference Standard: Utilized as an analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Academic & Industrial Research: Supports medicinal chemistry programs in universities and biotech firms exploring new pharmacophores and structure-activity relationships (SAR).

Basic Information

Product Name	Dibenzo(C,F)(1,2)Thiazepine, 6,11-Dihydro-6-Methyl-11-(2-(1-Pyrrolidinyl)Ethoxy)-, 5,5-Dioxide(Z)-2-Butenedioate (1:1)
CAS No.	155444-09-0
Molecular Formula	C24H26N2O7S
Molecular Weight	486.54 g/mol
Synonyms	(Z)-6,11-Dihydro-6-methyl-11-[2-(1-pyrrolidinyl)ethoxy]dibenzo[c,f][1,2]thiazepine 5,5-dioxide maleate (1:1); (Z)-6,11-Dihydro-6-methyl-11-[2-(pyrrolidin-1-yl)ethoxy]dibenzo[c,f][1,2]thiazepine 5,5-dioxide maleate; Maleic acid salt of (Z)-6,11-dihydro-6-methyl-11-[2-(1-pyrrolidinyl)ethoxy]dibenzo[c,f][1,2]thiazepine 5,5-dioxide; (Z)-Isomer of the maleate salt; DBTT-Maleate; Pharmaceutical Intermediate 155444-09-0.
EINECS	Contact for details

Quality Control

Our Dibenzo(C,F)(1,2)Thiazepine derivative is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, to ensure it meets the exacting standards required for pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, impurity profile, and residual solvents is provided with each shipment, supporting regulatory filings and cGMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccant use and a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (Z)-Isomer
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.