Description

Rosiglitazone Maleate is a high-purity active pharmaceutical ingredient (API) belonging to the thiazolidinedione class of compounds. It serves as a potent and selective agonist for the peroxisome proliferator-activated receptor gamma (PPARγ), making it a critical component in pharmaceutical research and development. This compound is primarily utilized by pharmaceutical manufacturers and research institutions focused on metabolic disorders. Its consistent quality and reliable supply are essential for advancing therapeutic applications and ensuring formulation stability.

Application

• Pharmaceutical API: Primary active ingredient in the formulation of antidiabetic medications.
• Reference Standard: Used in analytical laboratories for quality control and method validation of drug products.
• Biomedical Research: Critical tool for in vitro and in vivo studies investigating PPARγ pathways, insulin sensitization, and glucose metabolism.
• Drug Discovery & Development: Serves as a lead compound or comparator in the synthesis of novel therapeutic agents for type 2 diabetes.
• Formulation Development: Employed in pre-formulation and stability studies for solid dosage forms such as tablets.

Basic Information

Product Name	Rosiglitazone Maleate
CAS No.	155141-29-0
Molecular Formula	C22H27N3O6S
Molecular Weight	473.53 g/mol
Synonyms	Rosiglitazone (Z)-2-Butenedioate; 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, (Z)-2-Butenedioate; BRL 49653C; Avandia (Trade Name); PPARγ Agonist; (±)-5-[[4-[2-(Methyl(2-pyridinyl)amino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione (Z)-2-Butenedioate
EINECS	Contact for details

Quality Control

Our Rosiglitazone Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.