Description

n-[[3-[4-[4-(2-Cyanoethyl)-1-Piperazinyl]-3-Fluorophenyl]-2-Oxo-5-Oxazolidinyl]Methyl]Acetamide CAS NO 154590-46-2 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly within the antimicrobial and central nervous system therapeutic classes. It is primarily sought after by research institutions, custom synthesis organizations, and pharmaceutical manufacturers engaged in the development of next-generation therapeutics.

Application

• Key Intermediate in Novel Antibiotic Synthesis: Serves as a critical building block in the research and production of new-generation oxazolidinone-class antibiotics, targeting drug-resistant bacterial strains.
• Pharmaceutical Research & Development (R&D): Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and the creation of targeted molecular libraries.
• Custom Synthesis and Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the scale-up and cGMP production of client-specific drug candidates.
• Precursor for CNS-Active Compounds: Acts as a synthetic precursor in the development of potential therapeutics for neurological and psychiatric disorders.
• Process Chemistry Optimization: Used to develop and refine efficient, scalable synthetic routes for complex molecule manufacturing.
• Reference Standard and Analytical Testing: Provides a high-purity standard for quality control, method development, and regulatory submission support in API production.

Basic Information

Product Name	n-[[3-[4-[4-(2-Cyanoethyl)-1-Piperazinyl]-3-Fluorophenyl]-2-Oxo-5-Oxazolidinyl]Methyl]Acetamide
CAS No.	154590-46-2
Molecular Formula	C19H23FN6O3
Molecular Weight	402.43 g/mol
Synonyms	Acetamide, N-[[3-[4-[4-(2-cyanoethyl)-1-piperazinyl]-3-fluorophenyl]-2-oxo-5-oxazolidinyl]methyl]-; UNII-9QZ80IQL8P; 9QZ80IQL8P; 154590-46-2; (S)-N-(((5S)-3-(4-(4-(2-Cyanoethyl)piperazin-1-yl)-3-fluorophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide; (S)-N-(((5S)-3-(3-Fluoro-4-(4-(2-cyanoethyl)piperazin-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide; Aprepitant Intermediate; Oxazolidinone Piperazine Derivative.
EINECS	Contact for details

Quality Control

Our n-[[3-[4-[4-(2-Cyanoethyl)-1-Piperazinyl]-3-Fluorophenyl]-2-Oxo-5-Oxazolidinyl]Methyl]Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting pharmaceutical intermediate standards. Comprehensive Certificates of Analysis (COA) detailing all test results are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.