Description

4-(4-Boc-Piperazin-1-Yl)-3-Fluoroaniline is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine ring and an aniline moiety. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for creating novel drug candidates, particularly in oncology and CNS therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of small molecule drug candidates targeting various disease pathways.
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linker-warhead conjugates due to its amine functionality and Boc-protected piperazine.
• Kinase Inhibitor Synthesis: Serves as a precursor in the manufacture of potent and selective kinase inhibitors for cancer therapy.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for use in custom synthesis projects and scale-up campaigns under cGMP conditions.
• Academic Research: Used in university and institutional labs for exploratory medicinal chemistry and methodology development.

Basic Information

Product Name	4-(4-Boc-Piperazin-1-Yl)-3-Fluoroaniline
CAS No.	154590-35-9
Molecular Formula	C15H22FN3O2
Molecular Weight	295.36 g/mol
Synonyms	3-Fluoro-4-(4-Boc-piperazin-1-yl)aniline; 1-Boc-4-(2-Fluoro-4-aminophenyl)piperazine; 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-3-fluoroaniline; tert-Butyl 4-(2-fluoro-4-aminophenyl)piperazine-1-carboxylate; 154590-35-9; 3-Fluoro-4-(1-piperazinyl)aniline, N-Boc protected; 4-(N-Boc-piperazinyl)-3-fluoroaniline
EINECS	Contact for details

Quality Control

Our 4-(4-Boc-Piperazin-1-Yl)-3-Fluoroaniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with full traceability for every lot. Our quality commitment aligns with ICH guidelines, supporting its use in research and non-GMP development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.