Description

Dolichol (13~21) CAS NO 153857-77-3 is a high-purity, defined mixture of polyprenols, specifically a series of dolichols with chain lengths ranging from 13 to 21 isoprene units. This compound is a critical biochemical intermediate, essential for the biosynthesis of N-linked glycoproteins and glycolipids across various biological systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications in cell biology studies, enzyme research, and the development of therapeutic agents.

Application

• Biochemical Research: As a substrate for studying the enzymatic activity of dolichol kinase and dolichyl-phosphate mannose synthase in glycosylation pathways.
• Pharmaceutical Development: Investigation into its role as a carrier lipid in the biosynthesis of glycoproteins, relevant for drug targeting and vaccine development.
• Cell Culture & In Vitro Studies: Used in cell-based assays to understand protein glycosylation defects and related metabolic disorders.
• Enzyme Characterization: Serves as a standard or reagent for characterizing enzymes involved in the mevalonate pathway and post-translational modifications.
• Nutritional Science Research: Exploration of its antioxidant properties and potential role in cellular membrane stability and function.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in HPLC and LC-MS analyses.

Basic Information

Product Name	Dolichol (13~21)
CAS No.	153857-77-3
Molecular Formula	Mixture of C65H108O to C105H168O
Molecular Weight	~953.6 to ~1530.6 g/mol (for major components)
Synonyms	Polyprenol (C65-C105); Dolichols C13-C21; (all-E)-Polyprenol; α-Saturated Polyprenol; 2,3-Dihydropolyprenol; Dolichol mixture; Glycosyl Carrier Lipid; Undecaprenol-like lipid (long-chain)
EINECS	Contact for details

Quality Control

Our Dolichol (13~21) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and composition profiling, to ensure consistency and compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chromatographic profile is provided with every shipment to guarantee traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (HPLC)	Complies (Characteristic profile of C13-C21 dolichols)
Composition (HPLC Area %)	Dolichol-13 to Dolichol-21: ≥85% (total)
Purity (HPLC)	≥90% (Total dolichol content)
Solubility	Soluble in chloroform, hexane, ether; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.