Description

Aquastatin A CAS NO 153821-50-2 is a specialized chemical compound, a potent inhibitor of the enzyme squalene synthase. This compound is of significant value in biochemical research and pharmaceutical development for its role in studying cholesterol biosynthesis pathways. It is primarily sought after by researchers in the life sciences, pharmaceutical R&D, and biotechnology sectors for use as a critical reference standard and a tool compound in metabolic studies.

Application

• Biochemical Research: Used as a specific inhibitor to study the enzymatic activity of squalene synthase and its role in the mevalonate pathway.
• Pharmaceutical R&D: Serves as a key reference standard and tool compound in the discovery and development of novel cholesterol-lowering agents.
• Metabolic Pathway Analysis: Employed in cell-based and in vitro assays to investigate sterol biosynthesis and its regulation.
• Enzyme Inhibition Studies: Utilized to characterize inhibitor kinetics and the structure-activity relationship (SAR) of squalene synthase inhibitors.
• Academic Research: A critical reagent for universities and research institutions focusing on lipid metabolism, enzymology, and metabolic diseases.

Basic Information

Item	Details
Product Name	Aquastatin A
CAS No.	153821-50-2
Molecular Formula	C29H44O4
Molecular Weight	456.66 g/mol
Synonyms	Aquastatin A; Zarfacol 1; Squalestatin S1; Squalene Synthase Inhibitor S1; (3R,5R)-7-[(1R,2R,6S,8S,8aR)-2,6-Dimethyl-8-{[(2R)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic Acid; Zaragozic Acid A; L-669,262; Squalestatin 1
EINECS	Contact for details

Quality Control

Our Aquastatin A is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. For long-term storage, keep desiccated under an inert atmosphere. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.