Description

5-(Bromomethyl)-6-Iodo-1,3-Benzodioxole is a halogenated benzodioxole derivative, a versatile and high-value synthetic intermediate in advanced organic chemistry. Its unique bifunctional halogenation pattern makes it a critical building block for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on novel active ingredients, where precise functionalization is required.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring halogenated aromatic cores.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis.
• Material Science Research: Building block for creating functionalized polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: The iodine and bromine substituents make it an excellent substrate for sequential Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening in lead optimization.

Basic Information

Product Name	5-(Bromomethyl)-6-Iodo-1,3-Benzodioxole
CAS No.	153254-99-0
Molecular Formula	C8H6BrIO2
Molecular Weight	340.94 g/mol
Synonyms	6-Iodo-5-(bromomethyl)-1,3-benzodioxole; 1,3-Benzodioxole, 5-(bromomethyl)-6-iodo-; 5-Bromomethyl-6-iodo-1,3-benzodioxole; 6-Iodo-5-bromomethyl-1,3-benzodioxole; 153254-99-0; AI3-52362; CTK8G7222; ZINC000004055756; AKOS025310626; DB-088276; STL283910
EINECS	Contact for details

Quality Control

Our 5-(Bromomethyl)-6-Iodo-1,3-Benzodioxole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.