Description

Oligomycin F CAS NO 152726-68-6 is a potent and specific inhibitor of the mitochondrial ATP synthase complex, widely used as a critical research tool in biochemistry and cell biology. Its primary value lies in its ability to selectively block oxidative phosphorylation, making it indispensable for studying cellular energy metabolism, mitochondrial function, and apoptosis pathways. This high-purity compound is essential for researchers and developers in pharmaceutical R&D, academic institutions, and biotechnology companies focused on metabolic disorders, cancer research, and mitochondrial biology.

Application

• Mitochondrial Research: A key tool for studying the mechanism and regulation of ATP synthase (Complex V) and oxidative phosphorylation.
• Cell Biology & Apoptosis Studies: Used to investigate the role of mitochondrial membrane potential in programmed cell death and cellular stress responses.
• Metabolic Pathway Analysis: Employed in experiments to dissect glycolytic versus oxidative energy production in various cell types, including cancer cells.
• Pharmacology & Toxicology Screening: Serves as a reference compound in assays designed to identify novel modulators of mitochondrial function.
• Biochemical Assay Standard: Used to calibrate and validate assays measuring ATP production, oxygen consumption rate (OCR), and mitochondrial respiration.
• Academic & Industrial R&D: Fundamental reagent for basic research and drug discovery projects targeting energy-dependent processes.

Basic Information

Product Name	Oligomycin F
CAS No.	152726-68-6
Molecular Formula	C45H74O12
Molecular Weight	807.1 g/mol
Synonyms	Oligomycin F; Oligomycin F (Streptomyces diastatochromogenes); 26-Demethyloligomycin A; Antibiotic 1788F; Oligomycin complex component F; (1R,2S,5S,8S,9S,12R,13S,16S,19R,22S,25S,28S,31S,34R)-5,9,13,22,25,31-Hexamethyl-2,8,12,16,28,34-hexapropyl-3,36-dioxa-4-azatricyclo[30.3.1.04,19]hexatriacontane-10,14,20,26,32-pentaone
EINECS	Contact for details

Quality Control

Our Oligomycin F is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the purity, potency, and analytical results. We support research and development requiring reliable, high-grade biochemical inhibitors.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Biological Activity	Conforms to reference (Inhibits mitochondrial ATP synthase)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.