Description

(1R,4S)-tert-Butyl 2-Oxo-7-Azabicyclo[2.2.1]Heptane-7-Carboxylate CAS NO 152533-47-6 is a high-purity, chiral bicyclic lactam derivative that serves as a critical advanced pharmaceutical intermediate (API). Its value lies in its rigid, constrained structure, which is essential for imparting specific stereochemistry and biological activity in complex drug molecules. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring sophisticated chiral building blocks.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral drugs.
• Protease Inhibitor Scaffold: Utilized as a core structural motif in the research and development of protease inhibitors due to its lactam functionality.
• Asymmetric Synthesis: Employed as a building block in asymmetric synthesis to introduce the (1R,4S) stereochemistry into target molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Peptidomimetics Development: Acts as a conformationally restricted surrogate for amino acids in the design of peptidomimetic compounds.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for cGMP production of clinical trial materials and commercial drug substances.

Basic Information

Product Name	(1R,4S)-tert-Butyl 2-Oxo-7-Azabicyclo[2.2.1]Heptane-7-Carboxylate
CAS No.	152533-47-6
Molecular Formula	C11H17NO3
Molecular Weight	211.26 g/mol
Synonyms	7-(tert-Butoxycarbonyl)-7-azabicyclo[2.2.1]heptan-2-one; (1R,4S)-7-Boc-7-azabicyclo[2.2.1]heptan-2-one; (1R,4S)-2-Oxo-7-azabicyclo[2.2.1]heptane-7-carboxylic acid tert-butyl ester; tert-Butyl (1R,4S)-2-oxo-7-azabicyclo[2.2.1]heptane-7-carboxylate; (1R,4S)-Boc-7-azanorbornan-2-one; (1R,4S)-2-Oxo-7-Boc-7-azabicyclo[2.2.1]heptane; Bicyclic Lactam Boc Derivative
EINECS	Contact for details

Quality Control

Our (1R,4S)-tert-Butyl 2-Oxo-7-Azabicyclo[2.2.1]Heptane-7-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial methods, to ensure compliance with stringent specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.