Description

1-Propanone, 1-(4-(2-Hydroxy-3-(1-Pyrrolidinyl)Propoxy)-3-(Propoxymeth Yl)Phenyl)-, (E)-2-Butenedioate (2:1) (Salt) CAS NO 152271-10-8 is a high-purity, non-racemic salt form of a complex chiral ketone, designed for advanced chemical synthesis. This compound is valued for its role as a critical pharmaceutical intermediate and a versatile building block in the development of active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical sectors, where precise molecular structure and consistent quality are paramount.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug molecules, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component during the research and development of new chemical entities (NCEs).
• Asymmetric Synthesis: Used in stereoselective reactions to construct molecules with specific three-dimensional configurations critical for biological activity.
• Chemical Research: Employed in academic and industrial R&D laboratories for methodological studies and the exploration of new synthetic pathways.
• Process Chemistry Optimization: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.

Basic Information

Product Name	1-Propanone, 1-(4-(2-Hydroxy-3-(1-Pyrrolidinyl)Propoxy)-3-(Propoxymeth Yl)Phenyl)-, (E)-2-Butenedioate (2:1) (Salt)
CAS No.	152271-10-8
Molecular Formula	C22H33NO6 • 0.5C4H4O4
Molecular Weight	~ 456.52 g/mol (for salt form)
Synonyms	1-(4-(2-Hydroxy-3-(1-Pyrrolidinyl)propoxy)-3-(propoxymethyl)phenyl)-1-propanone fumarate (2:1); (E)-1-(4-(2-Hydroxy-3-(pyrrolidin-1-yl)propoxy)-3-(propoxymethyl)phenyl)propan-1-one hemifumarate; Fumarate salt of a pyrrolidinyl propanone derivative; Chiral ketone fumarate salt; Pharmaceutical intermediate 152271-10-8.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the exacting standards required for pharmaceutical applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to support regulatory filings. We are committed to cGMP principles where applicable to ensure supply chain integrity and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.