Description

tert-Butyl 4-(4-Iodophenyl)Tetrahydro-1(2H)-Pyrazinecarboxylate CAS NO 151978-66-4 is a high-purity, advanced pharmaceutical intermediate characterized by its iodophenyl and protected piperazine core structure. This compound is critical for enabling the synthesis of complex, biologically active molecules, particularly in medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of novel therapeutic agents, where its unique scaffold serves as a key building block.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and the development of novel drug candidates, leveraging the reactivity of the iodine moiety for further functionalization.
• Chemical Synthesis: Used in cross-coupling reactions (e.g., Suzuki, Sonogashira) due to the presence of the aryl iodide group, enabling the construction of complex molecular architectures.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales for new chemical entities.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical production.

Basic Information

Product Name	tert-Butyl 4-(4-Iodophenyl)Tetrahydro-1(2H)-Pyrazinecarboxylate
CAS No.	151978-66-4
Molecular Formula	C15H21IN2O2
Molecular Weight	388.25 g/mol
Synonyms	1-Boc-4-(4-iodophenyl)piperazine; tert-Butyl 4-(4-iodophenyl)piperazine-1-carboxylate; 4-(4-Iodophenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-4-(4-iodophenyl)piperazine; 4-(4-Iodophenyl)piperazine-1-carboxylic acid tert-butyl ester; Boc-4-(4-iodophenyl)piperazine; 151978-66-4; tert-Butyl 4-(4-iodobenzene)piperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Iodophenyl)Tetrahydro-1(2H)-Pyrazinecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and purity. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.