Description

Eupenifeldin is a specialized fungal metabolite belonging to the class of epipolythiodioxopiperazine alkaloids, identified by CAS No. 151803-45-1. This compound is of significant interest in life science research due to its potent biological activity, particularly as an inhibitor of hypoxia-inducible factor-1 (HIF-1). It serves as a critical research-grade biochemical for pharmaceutical discovery, enabling the study of cellular responses to low oxygen conditions and related therapeutic pathways.

Application

• Pharmaceutical Research & Development: A key reference standard and active agent in drug discovery programs targeting hypoxia-related diseases, including cancer, ischemic conditions, and pulmonary disorders.
• Biochemical Mechanism Studies: Used as a selective probe to investigate the HIF-1 signaling pathway, angiogenesis, and tumor cell metabolism in vitro.
• Academic & Institutional Research: Employed in university and government laboratories for fundamental studies in mycology, natural product chemistry, and cell biology.
• Biotech Screening Assays: Serves as a positive control or lead compound in high-throughput screening (HTS) assays designed to identify novel HIF-1 inhibitors.
• Reference Material for Analysis: Provides a certified standard for the qualitative and quantitative analysis (e.g., HPLC, LC-MS) of complex natural product extracts or fermentation broths.

Basic Information

Product Name	Eupenifeldin
CAS No.	151803-45-1
Molecular Formula	C27H30N2O6S2
Molecular Weight	542.67 g/mol
Synonyms	Eupenifeldin; Gliotoxin E; 11a,11a'-Didehydro-3,11a':3',11a-diepithio-3,3',11a,11a'-tetrahydro-6,6'-bi[1H-indole]-2,2',5,5'(4H,4'H)-tetrone; (3aR,11aR,11a'R,3a'S)-11a,11a'-Didehydro-3,11a':3',11a-diepithio-3,3',11a,11a'-tetrahydro-6,6'-bi[1H-indole]-2,2',5,5'(4H,4'H)-tetrone; HIF-1 Inhibitor
EINECS	Contact for details

Quality Control

Our Eupenifeldin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and is supplied with a comprehensive Certificate of Analysis (COA). We adhere to relevant standards for research chemicals to guarantee identity, purity, and stability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The product is light-sensitive (store away from light). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.