Description

(S)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-6-One is a high-purity, chiral heterocyclic compound that serves as a critical building block in advanced organic synthesis. Its defined stereochemistry and unique fused bicyclic structure make it an invaluable intermediate for constructing complex molecules with specific biological activity. This compound is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel drug candidates, especially for central nervous system (CNS) and metabolic disorder targets.
• Asymmetric Synthesis: Employed as a stereochemically defined scaffold for constructing complex, enantiomerically pure molecules in medicinal chemistry.
• Ligand and Catalyst Development: Used in the design and synthesis of novel chiral ligands and organocatalysts for asymmetric transformations.
• Chemical Biology Research: Serves as a core structure for developing molecular probes and tool compounds to study biological pathways.
• Peptidomimetics: The pyrrolopyrazinone core is utilized in the design of peptidomimetic compounds to modulate protein-protein interactions.
• Fine Chemical Production: An essential intermediate for the custom synthesis of specialty chemicals for advanced material science and agrochemical research.

Basic Information

Product Name	(S)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-6-One
CAS No.	151763-88-1
Molecular Formula	C7H12N2O
Molecular Weight	140.18 g/mol
Synonyms	(S)-Octahydropyrrolo[1,2-a]pyrazin-6-one; (6S)-Hexahydropyrrolo[1,2-a]pyrazin-6-one; (S)-1,2,3,4,6,7,8,8a-Octahydropyrrolo[1,2-a]pyrazin-6-one; L-Octahydropyrrolo[1,2-a]pyrazin-6-one; (S)-Perhydropyrrolo[1,2-a]pyrazin-6-one; (S)-HPP; Chiral Pyrrolopyrazinone
EINECS	Contact for details

Quality Control

Our (S)-Hexahydro-Pyrrolo[1,2-A]Pyrazin-6-One is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. We provide comprehensive analytical data, including chiral purity verification by HPLC. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and impurity profiles are available for every batch upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.