Description

Pramlintide is a synthetic analog of the human hormone amylin, designed to mimic its physiological effects. This peptide is of significant commercial and therapeutic importance for its role in glycemic control. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of treatments for diabetes mellitus.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the active component in injectable medications for the treatment of type 1 and type 2 diabetes.
• Diabetes Management Formulations: Used in combination with insulin therapy to improve postprandial glycemic control and reduce HbA1c levels.
• Biomedical Research: Serves as a critical reference standard and tool compound in metabolic disorder research, including studies on amylin physiology and insulin co-secretion.
• Drug Delivery System Development: Investigated in advanced formulation studies for sustained-release or novel delivery mechanisms to enhance patient compliance.
• Biosimilar & Generic Drug Development: A key target molecule for companies developing biosimilar or generic versions of branded amylin analog therapies.
• Clinical Trial Material (CTM): Supplied as a high-purity bulk active substance for use in Phase I-III clinical trials.

Basic Information

Item	Detail
Product Name	Pramlintide
CAS No.	151126-32-8
Molecular Formula	C171H267N51O53S2
Molecular Weight	3949.4 g/mol
Synonyms	Pramlintide Acetate; Symlin; AC-137; Amylin (1-37), 25-28-36-tridecapeptide analog; H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (disulfide bridge: 2-7); [25,28,29]Pro-h-amylin
EINECS	Contact for details

Quality Control

Our Pramlintide is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and assay, peptide mapping, and tests for related substances and residual solvents, ensuring it meets exacting standards for pharmaceutical use. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at a controlled room temperature of 15-25°C or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Purity (HPLC)	≥ 97.0% (Total related substances ≤ 3.0%)
Water Content (KF)	≤ 8.0%
Acetic Acid Content (HPLC)	5.0% - 12.0%
Peptide Content	≥ 80.0%
Bacterial Endotoxins	< 10 EU/mg
Sterility (where applicable)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.