Description

3-Butynoicacid,2-Amino-2-Methyl-,(2S)-(9Ci) is a chiral, non-natural amino acid derivative featuring a terminal alkyne functional group. This unique structure makes it a valuable versatile building block for the synthesis of complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on new active ingredients, peptide mimetics, and bioconjugation strategies.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of novel APIs (Active Pharmaceutical Ingredients), particularly in oncology and metabolic disease research.
• Peptidomimetics & Constrained Peptides: Used to introduce rigid, linear alkyne spacers into peptide backbones to study structure-activity relationships (SAR).
• Bioconjugation & Click Chemistry: The terminal alkyne enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling proteins, antibodies, and other biomolecules.
• Agrochemical Research: Building block for novel herbicides, fungicides, and plant growth regulators requiring specific chiral centers.
• Material Science: Monomer or cross-linker precursor for specialty polymers with tailored thermal or mechanical properties.
• Ligand Synthesis: Intermediate in the preparation of chiral ligands for asymmetric catalysis.

Basic Information

Item	Detail
Product Name	3-Butynoicacid,2-Amino-2-Methyl-,(2S)-(9Ci)
CAS No.	151074-96-3
Molecular Formula	C5H7NO2
Molecular Weight	113.11 g/mol
Synonyms	(2S)-2-Amino-2-methylbut-3-ynoic acid; D-2-Amino-2-methyl-3-butynoic acid; (S)-2-Amino-2-methylbut-3-ynoic acid; 2-Amino-2-methyl-3-butynoic acid, (S)-; 3-Butynoic acid, 2-amino-2-methyl-, (2S)-; Terminal alkyne amino acid; Chiral propiolic glycine derivative
EINECS	Contact for details

Quality Control

Every batch of our 3-Butynoicacid,2-Amino-2-Methyl-,(2S)-(9Ci) is produced and tested under strict quality management protocols to ensure high chiral purity and chemical consistency. Our products undergo rigorous quality testing, including chiral HPLC and NMR analysis, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture uptake, which can affect stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.