Description

3H-1,2,4-Triazol-3-One, 2,4-Dihydro-4-[4-[4-(4-Methoxyphenyl)-1-Piperazinyl]Phenyl]-2-(1-Methylpropyl)-, (R)- is a high-purity, chiral organic compound of significant interest in advanced pharmaceutical research and development. This molecule matters as a sophisticated chemical intermediate, offering a complex, stereochemically defined scaffold for creating novel active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on central nervous system (CNS) agents, receptor modulators, and other therapeutic candidates.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets.
• Biochemical Research: Used as a reference standard or probe compound in pharmacological studies to investigate receptor binding and enzyme inhibition.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of complex, stereospecific molecules.
• Asymmetric Synthesis: Utilized in the development of new catalytic or stoichiometric asymmetric methodologies due to its defined stereocenter.
• Preclinical Development: Supplied for use in the early-stage development of potential therapeutics, including in vitro and in vivo studies.

Basic Information

Item	Details
Product Name	3H-1,2,4-Triazol-3-One, 2,4-Dihydro-4-[4-[4-(4-Methoxyphenyl)-1-Piperazinyl]Phenyl]-2-(1-Methylpropyl)-, (R)-
CAS No.	149809-44-9
Molecular Formula	C24H31N5O2
Molecular Weight	421.54 g/mol
Synonyms	(R)-2,4-Dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one; (R)-Nefazodone Metabolite Hydroxynefazodone; (R)-2-[1-Methylpropyl]-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one; (R)-Hydroxynefazodone; (R)-CPM 1; (R)-Triazoledione derivative; (R)-enantiomer of a nefazodone-related compound
EINECS	Contact for details

Quality Control

Our 3H-1,2,4-Triazol-3-One derivative is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, NMR, and mass spectrometry for structural confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your critical R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.