Description

(2S-Cis)-3,6-Dioxo-5-(Phenylmethyl)-2-Piperazineacetonitrile is a high-purity chiral piperazine derivative and a key synthetic intermediate in advanced organic chemistry. Its value lies in its role as a sophisticated building block for constructing complex molecules with specific stereochemistry. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new therapeutic agents, particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the development of advanced, stereospecific pesticides and herbicides where the specific spatial orientation of the molecule is crucial for bioactivity.
• Asymmetric Catalysis Research: Serves as a precursor or ligand in the development of novel chiral catalysts for stereoselective synthesis.
• Peptidomimetic Chemistry: Employed as a constrained scaffold to mimic peptide structures in drug discovery programs, enhancing metabolic stability.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting cutting-edge research in medicinal and synthetic organic chemistry.
• Custom Synthesis: Used as a starting material for the contract manufacturing of specialized, high-value fine chemicals for client-specific projects.

Basic Information

Product Name	(2S-Cis)-3,6-Dioxo-5-(Phenylmethyl)-2-Piperazineacetonitrile
CAS No.	149796-08-7
Molecular Formula	C13H13N3O2
Molecular Weight	243.26 g/mol
Synonyms	5-Benzyl-2-(cyanomethyl)-cis-2,5-diazacyclohexane-1,4-dione; (2S,5S)-5-Benzyl-2-(cyanomethyl)piperazine-1,4-dione; 5-Benzyl-2-(cyanomethyl)piperazine-1,4-dione (cis-); (2S,5S)-5-Benzyl-2-(cyanomethyl)-1,4-diazacyclohexane-1,4-dione; 149796-08-7; (2S-cis)-5-Benzyl-2-(cyanomethyl)piperazine-1,4-dione; cis-5-Benzyl-2-(cyanomethyl)piperazine-1,4-dione
EINECS	Contact for details

Quality Control

Our (2S-Cis)-3,6-Dioxo-5-(Phenylmethyl)-2-Piperazineacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.