Description

Demethyl Curcumin is a bioactive curcuminoid derivative, structurally related to curcumin but with distinct physicochemical and biological properties. This compound is valued for its enhanced bioavailability and potent biological activity compared to its parent molecule, making it a critical intermediate and active ingredient in advanced research and development. It is primarily sought by the pharmaceutical, nutraceutical, and life science research industries for applications in drug discovery, formulation development, and the study of inflammatory and oxidative pathways.

Application

• Pharmaceutical Intermediates: Serves as a key building block for synthesizing novel therapeutic agents targeting inflammation, cancer, and neurodegenerative diseases.
• Nutraceutical & Dietary Supplements: Incorporated into high-end formulations for its enhanced bioavailability and potent antioxidant properties.
• Biomedical Research: Used as a reference standard and active compound in in vitro and in vivo studies to investigate cellular signaling pathways, apoptosis, and enzyme inhibition.
• Cosmeceuticals: Applied in advanced skincare products for its potential anti-aging and skin-protective effects.
• Functional Food & Beverage Additives: Explored for fortifying foods and drinks with bioactive, health-promoting ingredients.
• Chemical Synthesis & Process Development: Utilized as a specialty intermediate for creating novel analogs and derivatives in medicinal chemistry.

Basic Information

Product Name	Demethyl Curcumin
CAS No.	149732-51-4
Molecular Formula	C20H18O5
Molecular Weight	338.35 g/mol
Synonyms	Bisdemethoxycurcumin; Curcumin III; (1E,6E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione; Desmethoxycurcumin; 1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione; Natural Yellow 3; BDMC; p,p'-Dihydroxydicinnamoylmethane
EINECS	Contact for details

Quality Control

Our Demethyl Curcumin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets stringent specifications for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.