Description

(R)-2-Hydroxymethyl-Piperazine-2Hcl is a high-purity chiral piperazine derivative, a critical building block in asymmetric synthesis. Its value lies in providing a stereochemically defined scaffold for constructing complex molecules with high enantiomeric purity. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs), chiral catalysts, and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Asymmetric Catalyst Ligand Precursor: Used to synthesize sophisticated ligands for metal-catalyzed asymmetric reactions, enabling the production of enantiomerically pure compounds.
• Fine Chemical Synthesis: Serves as a versatile building block for creating complex, high-value specialty chemicals and agrochemical intermediates.
• Bioconjugation & Linker Chemistry: The hydroxymethyl and secondary amine functionalities make it suitable for constructing cleavable linkers in antibody-drug conjugates (ADCs) and bioconjugation applications.
• Academic & Process R&D: A valuable reagent for method development and scaling new synthetic routes in academic and industrial research laboratories.

Basic Information

Product Name	(R)-2-Hydroxymethyl-Piperazine-2Hcl
CAS No.	149715-47-9
Molecular Formula	C5H14N2O·2HCl
Molecular Weight	215.10 g/mol
Synonyms	(R)-2-(Hydroxymethyl)piperazine Dihydrochloride; (R)-Piperazine-2-methanol Dihydrochloride; (2R)-2-Piperazinemethanol Dihydrochloride; (R)-2-Hydroxymethylpiperazine Dihydrochloride; (R)-2-Piperazinemethanol Dihydrochloride; (R)-2-Methanolpiperazine 2HCl; (R)-HMPip·2HCl
EINECS	Contact for details

Quality Control

Our (R)-2-Hydroxymethyl-Piperazine-2Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.