Description

1-Piperazinecarboxylicacid,3-(Hydroxymethyl)-,Methylester,(R)-(9Ci) is a high-value, optically active piperazine derivative, a crucial chiral building block in modern synthetic chemistry. Its significance lies in its role as a key intermediate for constructing complex molecules with specific stereochemistry, essential for biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular targeting.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of advanced drug candidates, especially in oncology and central nervous system (CNS) research.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce enantioselectivity.
• Peptidomimetics Development: Serves as a constrained scaffold for designing and synthesizing peptide analogs with improved metabolic stability and bioavailability.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Potential intermediate in the development of new, stereospecific pesticides and herbicides.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-Piperazinecarboxylicacid,3-(Hydroxymethyl)-,Methylester,(R)-(9Ci)
CAS No.	149648-98-6
Molecular Formula	C7H14N2O3
Molecular Weight	174.20 g/mol
Synonyms	(R)-3-(Hydroxymethyl)piperazine-1-carboxylic acid methyl ester; Methyl (R)-3-(hydroxymethyl)piperazine-1-carboxylate; (R)-Methyl 3-(hydroxymethyl)piperazine-1-carboxylate; (R)-1-(Methoxycarbonyl)-3-(hydroxymethyl)piperazine; (R)-N-Carbomethoxy-3-hydroxymethylpiperazine; (R)-3-Hydroxymethyl-1-piperazinecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch is characterized and tested to ensure identity, purity, and enantiomeric excess meet the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing key parameters such as assay, chiral purity (enantiomeric excess), and impurity profile. We support development from milligram to kilogram scale with consistent quality and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, maintaining the material at 2-8°C under an inert atmosphere is recommended to preserve stability and chiral integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.